Synthesis of Spironucleosides: Past and Future Perspectives.

نویسندگان

  • Raquel G Soengas
  • Gustavo da Silva
  • Juan Carlos Estévez
چکیده

Spironucleosides are a type of conformationally restricted nucleoside analogs in which the anomeric carbon belongs simultaneously to the sugar moiety and to the base unit. This locks the nucleic base in a specific orientation around the N-glycosidic bond, imposing restrictions on the flexibility of the sugar moiety. Anomeric spiro-functionalized nucleosides have gained considerable importance with the discovery of hydantocidin, a natural spironucleoside isolated from fermentation broths of Streptomyces hygroscopicus which exhibits potent herbicidal activity. The biological activity of hydantocidin has prompted considerable synthetic interest in this nucleoside and also in a variety of analogues, since important pharmaceutical leads can be found among modified nucleoside analogues. We present here an overview of the most important advances in the synthesis of spironucleosides.

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عنوان ژورنال:
  • Molecules

دوره 22 11  شماره 

صفحات  -

تاریخ انتشار 2017